1,2,3-triazolo[4,5-f]quinolines: II: preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract
Academic Article
Publication Date:
1989
Short description:
1,2,3-triazolo[4,5-f]quinolines: II: preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract / Cappuccinelli, Pietro Antonio; Nuvole, Antonio Michele; Sanna, Paolo Antonio; Paglietti, Giuseppe; Zanetti, Stefania Anna Lucia; Juliano, Claudia Clelia Assunta. - In: IL FARMACO. - ISSN 0014-827X. - 44:6(1989), pp. 619-632.
abstract:
Some 6-ethyl-1(2)(3)-R-1(2)(3)H-triazolo[4,5-f]quinolin-9-one-8-carboxylic acids were prepared as novel analogues of oxolinic acid in order to evaluate the effect on antibacterial activity of the isosteric replacement of the dioxolic moiety with the triazole ring substituted in position 1 or 2. In vitro tests showed a good and selective activity against Escherichia coli (MIC 12.5 micrograms/ml) of compound (XVI).
Iris type:
1.1 Articolo in rivista
Keywords:
1,2,3-triazolo[4,5-f]quinolines; antibacterial activity;Escherichia coli
List of contributors:
Cappuccinelli, Pietro Antonio; Nuvole, Antonio Michele; Sanna, Paolo Antonio; Paglietti, Giuseppe; Zanetti, Stefania Anna Lucia; Juliano, Claudia Clelia Assunta
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