Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond
Articolo
Data di Pubblicazione:
2005
Citazione:
Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular
carbene insertion into a carbon-hydrogen bond / Muroni, Daniele; Saba, Antonio. - 13:(2005), pp. 1-7.
Abstract:
A convenient synthesis of tricyclic β-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of α-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl
chiral auxiliary, the β-lactam is obtained with 76% e.e.
chiral auxiliary, the β-lactam is obtained with 76% e.e.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Metal-carbene; diazoamide; C-H insertion; intramolecular cyclization; β-lactam; chemoselectivity; stereoselectivity
Elenco autori:
Muroni, Daniele; Saba, Antonio
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