Pharmacodynamic analysis of a fluid challenge with 4 ml kg-1 over 10 or 20 min: a multicenter cross-over randomized clinical trial
Academic Article
Publication Date:
2021
Short description:
Pharmacodynamic analysis of a fluid challenge with 4 ml kg-1 over 10 or 20 min: a multicenter cross-over randomized clinical trial / Messina, Antonio; Palandri, Chiara; De Rosa, Silvia; Danzi, Vinicio; Bonaldi, Efrem; Montagnini, Claudia; Baino, Sara; Villa, Federico; Sala, Francesca; Zito, Paola; Negri, Katerina; Della Corte, Francesco; Cammarota, Gianmaria; Saderi, Laura; Sotgiu, Giovanni; Monge García, Manuel Ignacio; Cecconi, Maurizio. - In: JOURNAL OF CLINICAL MONITORING AND COMPUTING. - ISSN 1387-1307. - (2021). [10.1007/s10877-021-00756-3]
abstract:
A number of studies performed in the operating room evaluated the hemodynamic effects of the fluid challenge (FC), solely considering the effect before and after the infusion. Few studies have investigated the pharmacodynamic effect of the FC on hemodynamic flow and pressure variables. We designed this trial aiming at describing the pharmacodynamic profile of two different FC infusion times, of a fixed dose of 4 ml kg-1.
Iris type:
1.1 Articolo in rivista
Keywords:
Fluid challenge; Fluid responsiveness; Fluids; Hemodynamics; Neurosurgery; Pharmacodynamic
List of contributors:
Messina, Antonio; Palandri, Chiara; De Rosa, Silvia; Danzi, Vinicio; Bonaldi, Efrem; Montagnini, Claudia; Baino, Sara; Villa, Federico; Sala, Francesca; Zito, Paola; Negri, Katerina; Della Corte, Francesco; Cammarota, Gianmaria; Saderi, Laura; Sotgiu, Giovanni; Monge García, Manuel Ignacio; Cecconi, Maurizio
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