Publication Date:
2016
Short description:
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers / Hatakeyama, H., Wu, S.Y., Lyons, Y.A., Pradeep, S., Wang, W., Huang, Q., Court, K.A., Liu, T., Nie, S., Rodriguez-Aguayo, C., Shen, F., Huang, Y., Hisamatsu, T., Mitamura, T., Jennings, N., Shim, J., Dorniak, P.L., Mangala, L.S., Petrillo, M., Petyuk, V.A., et al.. - In: CELL REPORTS. - ISSN 2211-1247. - 17:6(2016), pp. 1621-1631. [10.1016/j.celrep.2016.10.020]
abstract:
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
Iris type:
1.1 Articolo in rivista
Keywords:
copper sulfide nanoparticle; CTGF; DOPC-liposome; hyperthermia; ovarian cancer; thermosensitivity
List of contributors:
Hatakeyama, H.; Wu, S. Y.; Lyons, Y. A.; Pradeep, S.; Wang, W.; Huang, Q.; Court, K. A.; Liu, T.; Nie, S.; Rodriguez-Aguayo, C.; Shen, F.; Huang, Y.; Hisamatsu, T.; Mitamura, T.; Jennings, N.; Shim, J.; Dorniak, P. L.; Mangala, L. S.; Petrillo, M.; Petyuk, V. A.; Schepmoes, A. A.; Shukla, A. K.; Torres-Lugo, M.; Lee, J. -S.; Rodland, K. D.; Fagotti, A.; Lopez-Berestein, G.; Li, C.; Sood, A. K.
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