Cu–iminopyridine complexes as catalysts for carbene and nitrene transfer reactions

Copper complexes with chiral iminopyridine ligands were screened for their catalytic efficiency in carbene (cyclopropanation)
and nitrene transfer reactions (aziridination, C–H amidation). Both pre-formed and in situ formed complexes were considered.
The results highlighted the poor catalytic efficiency of these complexes in cyclopropanation reactions employing methyl
phenyldiazoacetate as the carbene source, whereas better results were obtained in nitrene transfer reactions, particularly in
the amidation of C–H bonds, albeit the enantioselectivity of the reactions was negligible in nearly all cases. Finally, copper complexes
were also found to promote an interesting oxidative functionalization of alkynes with PhI(OAc)2 at room temperature.