Potentiometric, voltammetric and spectroscopic studies of fisetin and its copper complexes.

Fisetin is a naturally occurring bioactive plant compound of immense importance as a potentially useful therapeutic drug, for various free radical mediated as well as other diseases. The chelation of metals could be crucial in the prevention of radical generation which damage target biomolecules. Therefore, research on the metal flavonoid complexes is very helpful in developing new medicines, based on these complexes. Copper ions play an important role in biological systems and wherefore they are very popular in the area of biomedical research and bioinorganic chemistry. Therefore, copper was the subject of our investigation to determine chelating efficiency of fisetin. The purpose of these studies was to determine and characterize complexes formed in different pH range. Potentiometric titration, cyclic voltammetry and spectroscopic techniques: UV-Vis, ESI MS were applied to characterize physicochemical properties of fisetin and copper complexes.