Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD
Academic Article
Publication Date:
2020
Short description:
Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD / Arru, G., Sechi, E., Mariotto, S., Zarbo, I.R., Ferrari, S., Gajofatto, A., Monaco, S., Deiana, G.A., Bo, M., Sechi, L.A., Sechi, G.P.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 338:(2020), p. 577110. [10.1016/j.jneuroim.2019.577110]
abstract:
Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.
Iris type:
1.1 Articolo in rivista
Keywords:
Autoimmunity; Human endogenous retroviruses; MS; Myelin oligodendrocyte glycoprotein; Neuromyelitis optica spectrum disorder; Adult; Aged; Aged, 80 and over; Aquaporin 4; Autoantibodies; Female; Gene Products, env; Humans; Immunoglobulin G; Male; Middle Aged; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuromyelitis Optica; Pregnancy Proteins; Retrospective Studies
List of contributors:
Arru, G.; Sechi, E.; Mariotto, S.; Zarbo, I. R.; Ferrari, S.; Gajofatto, A.; Monaco, S.; Deiana, G. A.; Bo, M.; Sechi, L. A.; Sechi, G. P.
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