Acanthamoeba castellanii promotion of the in vitro survival and transmission of Coxsackie-B-3 viruses
Academic Article
Publication Date:
2006
Short description:
Acanthamoeba castellanii promotion of the in vitro survival and transmission of Coxsackie-B-3 viruses / Mattana, A., Serra, C., E., M., G., D., Fiori, P.L., P., C.. - In: EUKARYOTIC CELL. - ISSN 1535-9778. - 5:(2006), pp. 665-671.
abstract:
This work was undertaken to determine whether Acanthamoeba could play a role in the survival and
transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and
coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed
a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was
independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that
virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the
basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and
their transmission to human hosts.
transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and
coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed
a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was
independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that
virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the
basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and
their transmission to human hosts.
Iris type:
1.1 Articolo in rivista
List of contributors:
Mattana, Antonella; Serra, Caterina; E., Mariotti; G., Delogu; Fiori, Pier Luigi; P., Cappuccinelli
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