Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Academic Article
Publication Date:
2019
Short description:
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences / Karlsson Linnér, R., Biroli, P., Kong, E., Meddens, S.F.W., Wedow, R., Fontana, M.A., Lebreton, M., Tino, S.P., Abdellaoui, A., Hammerschlag, A.R., Nivard, M.G., Okbay, A., Rietveld, C.A., Timshel, P.N., Trzaskowski, M., Vlaming, R.d., Zünd, C.L., Bao, Y., Buzdugan, L., Caplin, A.H., et al.. - In: NATURE GENETICS. - ISSN 1546-1718. - 51:2(2019), pp. 245-257. [10.1038/s41588-018-0309-3]
abstract:
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (∣r̂ g ∣ ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
Iris type:
1.1 Articolo in rivista
Keywords:
Genetics
List of contributors:
Karlsson Linnér, Richard; Biroli, Pietro; Kong, Edward; Meddens, S. Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Maël; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; Vlaming, Ronald de; Zünd, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H.; Chen, Chia-Yen; Eibich, Peter; Fontanillas, Pierre; Gonzalez, Juan R.; Joshi, Peter K.; Karhunen, Ville; Kleinman, Aaron; Levin, Remy Z.; Lill, Christina M.; Meddens, Gerardus A.; Muntané, Gerard; Sanchez-Roige, Sandra; Rooij, Frank J. van; Taskesen, Erdogan; Wu, Yang; Zhang, Futao; Agee, Michelle; Alipanahi, Babak; Bell, Robert K.; Bryc, Katarzyna; Elson, Sarah L.; Furlotte, Nicholas A.; Huber, Karen E.; Litterman, Nadia K.; Mccreight, Jennifer C.; Mcintyre, Matthew H.; Mountain, Joanna L.; Northover, Carrie A. M.; Pitts, Steven J.; Sathirapongsasuti, J. Fah; Sazonova, Olga V.; Shelton, Janie F.; Shringarpure, Suyash; Tian, Chao; Tung, Joyce Y.; Vacic, Vladimir; Wilson, Catherine H.; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Andiappan, Anand; Awadalla, Philip; Battle, Alexis; Beutner, Frank; Jan Bonder, Marc; Boomsma, Dorret I.; Christiansen, Mark; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; Frayling, Timothy; Gharib, Sina A.; Gibson, Gregory; Heijmans, Bastiaan; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johannes; Kim, Yungil; Kirsten, Holger; Kovacs, Peter; Krohn, Knut; Kronberg-Guzman, Jaanika; Kukushkina, Viktorija; Kutalik, Zoltan; Lee, Bernett; Lehtimäki, Terho; Loeffler, Markus; Marigorta, Urko M.; Metspalu, Andres; Milani, Lili; Montgomery, Grant W.; Müller-Nurasyid, Martina; Nauck, Matthias; Nivard, Michel G.; Penninx, Brenda; Perola, Markus; Pervjakova, Natalia; Pierce, Brandon; Powell, Joseph; Prokisch, Holger; Psaty, Bruce M.; Raitakari, Olli; Ring, Susan; Ripatti, Samuli; Rotzchke, Olaf; Rüeger, Sina; Saha, Ashis; Scholz, Markus; Schramm, Katharina; Seppälä, Ilkka; Stumvoll, Michael; Sullivan, Patrick; Hoen, Peter-Bram t; Teumer, Alexander; Thiery, Joachim; Tong, Lin; Tönjes, Anke; Dongen, Jenny van; Meurs, Joyce van; Verlouw, Joost; Visscher, Peter M.; Völker, Uwe; Võsa, Urmo; Westra, Harm-Jan; Yaghootkar, Hanieh; Yang, Jian; Zeng, Biao; Zhang, Futao; Okbay, Aysu; Beauchamp, Jonathan P.; Fontana, Mark Alan; Lee, James J.; Pers, Tune H.; Rietveld, Cornelius A.; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S. Fleur W.; Oskarsson, Sven; Pickrell, Joseph K.; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S.; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda; Brandsma, Johannes H.; Concas, Maria Pina; Derringer, Jaime; Furlotte, Nicholas A.; Galesloot, Tessel E.; Girotto, Giorgia; Gupta, Richa; Hall, Leanne M.; Harris, Sarah E.; Hofer, Edith; Horikoshi, Momoko; Huffman, Jennifer E.; Kaasik, Kadri; Kalafati, Ioanna P.; Karlsson, Robert; Kong, Augustine; Lahti, Jari; Lee, Sven J. van der; de Leeuw, Christiaan; Lind, Penelope A.; Lindgren, Karl-Oskar; Liu, Tian; Mangino, Massimo; Marten, Jonathan; Mihailov, Evelin; Miller, Michael B.; Most, Peter J. van der; Oldmeadow, Christopher; Payton, Antony; Pervjakova, Natalia; Peyrot, Wouter J.; Qian, Yong; Raitakari, Olli; Rueedi, Rico; Salvi, Erika; Schmidt, Börge; Schraut, Katharina E.; Shi, Jianxin; Smith, Albert V.; Poot, Raymond A.; Pourcain, Beate St; Teumer, Alexander; Thorleifsson, Gudmar; Verweij, Niek; Vuckovic, Dragana; Wellmann, Juergen; Westra, Harm-Jan; Yang, Jingyun; Zhao, Wei; Zhu, Zhihong; Alizadeh, Behrooz Z.; Amin, Najaf; Bakshi, Andrew; Baumeister, Sebastian E.; Biino, Ginevra; Bønnelykke, Klaus; Boyle, Patricia A.; Campbell, Harry; Cappuccio, Francesco P.; Davies, Gail; De Neve, Jan-Emmanuel; Deloukas, Panos; Demuth, Ilja; Ding, Jun; Eibich, Peter; Eisele, Lewin; Eklund, Niina; Evans, David
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