The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease
Academic Article
Publication Date:
2009
Short description:
The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease / Dolei, Antonina; Perron, H.. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 15:(2009), pp. 4-13.
abstract:
This mini-review summarizes current knowledge of MSRV (multiple
sclerosis-associated retrovirus), founder member of the type W family of human
endogenous retroviruses (HERVs), its pathogenic potential and association with
diseases. As retrotransposable elements, HERVs behave differently from stable
genes, and cannot be studied with "Mendelian genetics" concepts only. They also
display complex interactions with other HERV families, and with classical
viruses. These concepts may contribute to unravelling the etiopathogenesis of
complex diseases such as multiple sclerosis, schizophrenia, and other chronic
multifactorial diseases.
sclerosis-associated retrovirus), founder member of the type W family of human
endogenous retroviruses (HERVs), its pathogenic potential and association with
diseases. As retrotransposable elements, HERVs behave differently from stable
genes, and cannot be studied with "Mendelian genetics" concepts only. They also
display complex interactions with other HERV families, and with classical
viruses. These concepts may contribute to unravelling the etiopathogenesis of
complex diseases such as multiple sclerosis, schizophrenia, and other chronic
multifactorial diseases.
Iris type:
1.1 Articolo in rivista
List of contributors:
Dolei, Antonina; Perron, H.
Published in: