Glucose-6-phosphate dehydrogenase (G6PD) deficiency in nonarteritic anterior ischemic optic neuropathy in a Sardinian population, Italy
Academic Article
Publication Date:
2008
Short description:
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in nonarteritic anterior ischemic optic neuropathy in a Sardinian population, Italy / Pinna, Antonio; Solinas, Maria Giuliana; Masia, C; Zinellu, A; Carru, C; Carta, A.. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - 49:(2008), pp. 1328-1332. [10.1167/iovs.07-1115]
abstract:
PURPOSE. Glucose-6-phosphate dehydrogenase (G6PD) defi-
ciency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against
ischemic heart and cerebrovascular disease and retinal vein
occlusion. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with nonarteritic anterior ischemic optic neuropathy (NAION) and ascertain whether G6PD deficiency may offer protection against
NAION.
METHODS. Erythrocyte G6PD activity was determined by using
a quantitative assay in 140 patients with NAION and 280 ageand gender-matched comparison patients. Conditional logistic
regression models were used to investigate the association
between G6PD deficiency and NAION.
RESULTS. G6PD deficiency was found in 7 (5%) patients with
NAION and 34 (12.1%) control subjects. Differences between
cases and controls were statistically significant (P 0.02).
Conditional logistic regression analysis, including as covariates
G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk for NAION (odds ratio [OR] 0.4,
95% confidence interval [CI] 0.17– 0.94, P 0.035). Conditional logistic regression analyses, including systolic or diastolic blood pressure and plasma glucose and cholesterol levels
confirmed that G6PD deficiency was associated with a decreased risk for NAION, but the ORs were not significant at the
0.05 significance level (P 0.085 and P 0.071). Models
including gender G6PD deficiency interaction disclosed that
gender was not an effect modifier of G6PD deficiency (P
0.20).
CONCLUSIONS. The frequency of G6PD deficiency in patients
with NAION was significantly lower than expected. Results
suggest that G6PD-deficient patients in the Sardinian population have a significantly decreased risk of having NAION.
ciency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against
ischemic heart and cerebrovascular disease and retinal vein
occlusion. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with nonarteritic anterior ischemic optic neuropathy (NAION) and ascertain whether G6PD deficiency may offer protection against
NAION.
METHODS. Erythrocyte G6PD activity was determined by using
a quantitative assay in 140 patients with NAION and 280 ageand gender-matched comparison patients. Conditional logistic
regression models were used to investigate the association
between G6PD deficiency and NAION.
RESULTS. G6PD deficiency was found in 7 (5%) patients with
NAION and 34 (12.1%) control subjects. Differences between
cases and controls were statistically significant (P 0.02).
Conditional logistic regression analysis, including as covariates
G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk for NAION (odds ratio [OR] 0.4,
95% confidence interval [CI] 0.17– 0.94, P 0.035). Conditional logistic regression analyses, including systolic or diastolic blood pressure and plasma glucose and cholesterol levels
confirmed that G6PD deficiency was associated with a decreased risk for NAION, but the ORs were not significant at the
0.05 significance level (P 0.085 and P 0.071). Models
including gender G6PD deficiency interaction disclosed that
gender was not an effect modifier of G6PD deficiency (P
0.20).
CONCLUSIONS. The frequency of G6PD deficiency in patients
with NAION was significantly lower than expected. Results
suggest that G6PD-deficient patients in the Sardinian population have a significantly decreased risk of having NAION.
Iris type:
1.1 Articolo in rivista
List of contributors:
Pinna, Antonio; Solinas, Maria Giuliana; Masia, C; Zinellu, A; Carru, C; Carta, A.
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