Step by step palladium mediated syntheses of new 2-(pyridin-2-yl)-6-R-nicotinic acids and esters RID D-3096-2011
Academic Article
Publication Date:
2010
Short description:
Step by step palladium mediated syntheses of new 2-(pyridin-2-yl)-6-R-nicotinic acids and esters RID D-3096-2011 / Petretto, G.L., Zucca, A., Stoccoro, S., Cinellu, M.A., Minghetti, G.. - In: JOURNAL OF ORGANOMETALLIC CHEMISTRY. - ISSN 0022-328X. - 695:2(2010), pp. 7.256-7.259. [10.1016/j.jorganchem.2009.10.002]
abstract:
Taking advantage of palladium peculiar ‘‘rollover” C,N cyclometallation, it is possible to promote C(3)
functionalization of 6-alkyl-substituted-2,20-bipyridines. The carbonylation reaction of rollover species
[Pd(Ln)Cl]2, (HL1 = 6-isopropyl-2,20-bipy, 1; HL2 = 6-neopentyl-2,20-bipy, 2; HL3 = 6-ethyl-2,20-bipy, 3;
HL4 = 6-methyl-2,20-bipy, 4) allowed the synthesis of 2-(pyridin-2-yl)-6-alkyl-nicotinic acids or esters.
These nicotinic derivatives are extremely rare and, as far as we know, quite unreported in the case of
the 6-substituted molecules.
functionalization of 6-alkyl-substituted-2,20-bipyridines. The carbonylation reaction of rollover species
[Pd(Ln)Cl]2, (HL1 = 6-isopropyl-2,20-bipy, 1; HL2 = 6-neopentyl-2,20-bipy, 2; HL3 = 6-ethyl-2,20-bipy, 3;
HL4 = 6-methyl-2,20-bipy, 4) allowed the synthesis of 2-(pyridin-2-yl)-6-alkyl-nicotinic acids or esters.
These nicotinic derivatives are extremely rare and, as far as we know, quite unreported in the case of
the 6-substituted molecules.
Iris type:
1.1 Articolo in rivista
Keywords:
Cyclopalladated compounds; nitrogen ligands; organic synthesis
List of contributors:
Petretto, Giacomo Luigi; Zucca, Antonio; Stoccoro, Sergio; Cinellu, Maria Agostina; Minghetti, G.
Published in: