Data di Pubblicazione:
2017
Citazione:
Para-aminosalicylic acid in the treatment of manganese toxicity / Lachowicz, J. I.; Nurch G. Crisponi, V. M. Nurch G. Crisponi; Aaseth, J.; Zoroddu, Maria Antonietta; Medici, Serenella; Peana, Massimiliano Francesco. - In: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. - ISSN 0946-672X. - 41:s1(2017), pp. 13-13.
Abstract:
Manganese excess associated with occupational and environmental
exposure can induce acute effects, with a syndrome known
as manganism, similar for a number of symptoms to Parkinson’s
disease. A possible remedy should be chelation therapy. Paraaminosalicylic
acid (PAS) in its use in China demonstrated effective
in reducing symptoms of manganism. There is evidence of a Nacetylated
metabolite (AcPAS) that seems effective in reducing
manganese levels in brain. Based on these reports we studied the
protonation and the complex formation equilibria of PAS and of
AcPAS with the target metal ion Mn2+. This study has documented
a substantial Mn chelating potential of both ligands. In the actual
case, the metabolism of PAS leads to a derivative with unusual
stronger chelating ability than the parent molecule. It is presumed
that the relatively small molecule Ac-PAS can penetrate across the
blood-to-brain border and exert its Mn2+ mobilizing action intracellularly.
exposure can induce acute effects, with a syndrome known
as manganism, similar for a number of symptoms to Parkinson’s
disease. A possible remedy should be chelation therapy. Paraaminosalicylic
acid (PAS) in its use in China demonstrated effective
in reducing symptoms of manganism. There is evidence of a Nacetylated
metabolite (AcPAS) that seems effective in reducing
manganese levels in brain. Based on these reports we studied the
protonation and the complex formation equilibria of PAS and of
AcPAS with the target metal ion Mn2+. This study has documented
a substantial Mn chelating potential of both ligands. In the actual
case, the metabolism of PAS leads to a derivative with unusual
stronger chelating ability than the parent molecule. It is presumed
that the relatively small molecule Ac-PAS can penetrate across the
blood-to-brain border and exert its Mn2+ mobilizing action intracellularly.
Tipologia CRIS:
1.5 Abstract in rivista
Elenco autori:
Lachowicz, J. I.; Nurch G. Crisponi, V. M. Nurch G. Crisponi; Aaseth, J.; Zoroddu, Maria Antonietta; Medici, Serenella; Peana, Massimiliano Francesco
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