Publication Date:
2013
Short description:
P 53 Codon 72 and Past Malaria Morbidity in Sardinia / Gloria Bottini, F; Meloni, Gianfranco; Saccucci, P; Bottini, E.. - In: MALARIA CHEMOTHERAPY, CONTROL & ELIMINATION. - ISSN 2090-2778. - 2:1(2013), pp. 107-107. [10.4172/2090-2778.1000107]
abstract:
p53 codon 72 genotypes in
Nuoro and Oristano areas: *Arg/*Arg genotype is much more frequent
in Oristano than in Nuoro (p=0.024). The frequency of *Arg allele is
82.6% in Oristano and 69.1% in Nuoro (p=0.04).
In accordance with experimental studies suggesting apoptosis of
the liver cells as a defense mechanism against parasite invasion, *Arg
allele favoring apoptosis seems to have been selected positively in area
of Sardinia exposed in the past to heavy malaria endemia.
Nuoro and Oristano areas: *Arg/*Arg genotype is much more frequent
in Oristano than in Nuoro (p=0.024). The frequency of *Arg allele is
82.6% in Oristano and 69.1% in Nuoro (p=0.04).
In accordance with experimental studies suggesting apoptosis of
the liver cells as a defense mechanism against parasite invasion, *Arg
allele favoring apoptosis seems to have been selected positively in area
of Sardinia exposed in the past to heavy malaria endemia.
Iris type:
1.1 Articolo in rivista
Keywords:
P 53 Codon 72; Malaria; Sardinia
List of contributors:
Gloria Bottini, F; Meloni, Gianfranco; Saccucci, P; Bottini, E.
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