The sequence and phylogenesis of the α-globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon) and Cyprus mouflon (Ovis aries ophion)
Articolo
Data di Pubblicazione:
2009
Citazione:
The sequence and phylogenesis of the α-globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon) and Cyprus mouflon (Ovis aries ophion) / Pirastru, Monica; Multineddu, C; Mereu, Paolo; Sannai, M; Sherbini, E. S.; Hadjisterkotis, E; Nàhlik, A; Franceschi, P; Manca, Laura; Masala, B.. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART D, GENOMICS & PROTEOMICS. - ISSN 1744-117X. - 4:(2009), pp. 168-173. [10.1016/j.cbd.2009.02.002]
Abstract:
In order to investigate the polymorphism of α-globin chain of hemoglobin amongst caprines, the linked Iα
and IIα globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries
musimon), and Cyprus mouflon (Ovis aries ophion) were completely sequenced, including the 5′ and 3′
untranslated regions. European and Cyprus mouflons, which do not show polymorphic α globin chains, had
almost identical α globin genes, whereas Barbary sheep exhibit two different chains encoded by two
nonallelic genes. Four different α genes were observed and sequenced in goat, validating previous
observations of the existence of allelic and nonallelic polymorphism. As in other vertebrates, interchromosomal
gene conversion appears to be responsible for such polymorphism. Evaluation of nucleotide sequences
at the level of molecular evolution of the Iα-globin gene family in the caprine taxa suggests a closer
relationship between the genus Ammotragus and Capra. Molecular clock estimates suggest sheep-mouflon,
goat-aoudad, and ancestor-caprine divergences of 2.8, 5.7, and 7.1 MYBP, respectively.
and IIα globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries
musimon), and Cyprus mouflon (Ovis aries ophion) were completely sequenced, including the 5′ and 3′
untranslated regions. European and Cyprus mouflons, which do not show polymorphic α globin chains, had
almost identical α globin genes, whereas Barbary sheep exhibit two different chains encoded by two
nonallelic genes. Four different α genes were observed and sequenced in goat, validating previous
observations of the existence of allelic and nonallelic polymorphism. As in other vertebrates, interchromosomal
gene conversion appears to be responsible for such polymorphism. Evaluation of nucleotide sequences
at the level of molecular evolution of the Iα-globin gene family in the caprine taxa suggests a closer
relationship between the genus Ammotragus and Capra. Molecular clock estimates suggest sheep-mouflon,
goat-aoudad, and ancestor-caprine divergences of 2.8, 5.7, and 7.1 MYBP, respectively.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Phylogeny; α-globin gene; Ammotragus lervia
Elenco autori:
Pirastru, Monica; Multineddu, C; Mereu, Paolo; Sannai, M; Sherbini, E. S.; Hadjisterkotis, E; Nàhlik, A; Franceschi, P; Manca, Laura; Masala, B.
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