Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound.
Articolo
Data di Pubblicazione:
2014
Citazione:
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound / Messori, L; Scaletti, F; Massai, L; Cinellu, Maria Agostina; Russo Krauss, I; di Martino, G; Vergara, A; Paduano, L; Merlino, A.. - In: METALLOMICS. - ISSN 1756-5901. - 6:(2014), pp. 233-236.
Abstract:
The reaction of Auoxo6, a dinuclear gold(III) complex, with the
model protein bovine pancreatic ribonuclease is explored here by
X-ray diffraction and ESI mass spectrometry. Data provide clues on
the processes of adduct formation and of enzyme inhibition and,
inductively, on the likely mode of action of this metallodrug.
model protein bovine pancreatic ribonuclease is explored here by
X-ray diffraction and ESI mass spectrometry. Data provide clues on
the processes of adduct formation and of enzyme inhibition and,
inductively, on the likely mode of action of this metallodrug.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
gold-based drugs; ribonuclease A; crystal structure
Elenco autori:
Messori, L; Scaletti, F; Massai, L; Cinellu, Maria Agostina; Russo Krauss, I; di Martino, G; Vergara, A; Paduano, L; Merlino, A.
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