A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study
Articolo
Data di Pubblicazione:
2015
Citazione:
A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study / Benedetti Maria, Donata; Pugliatti, Maura; Dalessandro, Roberto; Beghi, Ettore; Chiò, Adriano; Logroscino, Giancarlo; Filippini, Graziella; Galeotti, Francesca; Massari, Marco; Santuccio, Carmela; Raschetti, Roberto. - In: NEUROEPIDEMIOLOGY. - ISSN 0251-5350. - 45:2(2015), pp. 90-99. [10.1159/000438752]
Abstract:
BACKGROUND:
To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS.
METHODS:
All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions.
RESULTS:
We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01).
CONCLUSIONS:
In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS.
METHODS:
All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions.
RESULTS:
We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01).
CONCLUSIONS:
In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Axonal and demyelinating GBS; Guillain-Barré syndrome; Incidence; Prospective study; Trend; Epidemiology; Neurology (clinical)
Elenco autori:
Benedetti Maria, Donata; Pugliatti, Maura; Dalessandro, Roberto; Beghi, Ettore; Chiò, Adriano; Logroscino, Giancarlo; Filippini, Graziella; Galeotti, Francesca; Massari, Marco; Santuccio, Carmela; Raschetti, Roberto
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