Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test
Articolo
Data di Pubblicazione:
2015
Citazione:
Synergistic interaction between tapentadol and flupirtine in the rat
orafacial formalin test / Lee, Hk; DE VITO, Virginia; Giorgi, M; Yun, H.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 762:(2015), pp. 350-356.
Abstract:
Combination therapywithtwoormoreanalgesicsiswidelyusedforconditionsassociatedwithmod-
eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe
risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof
tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir
synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2,
5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth
phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg)
induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective
than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of
0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP
and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpain
eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe
risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof
tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir
synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2,
5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth
phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg)
induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective
than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of
0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP
and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpain
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Lee, Hk; DE VITO, Virginia; Giorgi, M; Yun, H.
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