EX VIVO PERMEATION THROUGH PORCINE ORAL MUCOUS MEMBRANE OF SALVIA DESOLEANA ATZEI & PICCI ESSENTIAL OIL FROM TOPICAL FORMULATIONS

In previous studies (1-3), we found !hat tbe essential oils of some Lamiaceae were able to produce marked inhibition of carrageelÙn- and histanùne- induced oedemas in laboratory animals, to reduce hyperalgesia caused by tbe admilÙstration of formic acid and also to have moderate anti-microbial action. These activities suggested tbeir possible use in tbe local treaunent of inflammatory conditions, especially in the stomatological field. In this work wc studied thc capacity of Salvia desoleana Atzei & Picci cssential oiI to permeate tbe porcine oral mucous, tbe cffects of tbe different formulations of tbe permeation and tbc cnhancer cfIect ofthe ethoxydiglicol Transcutol4