EXPLORATION OF BRAINSTEM FUNCTION THROUGH VESTIBULAR AND TRIGEMINAL REFLEXES IN HEALTHY PEOPLE AND IN PATIENTS WITH MULTIPLE SCLEROSIS
Abstract
Data di Pubblicazione:
2011
Citazione:
EXPLORATION OF BRAINSTEM FUNCTION THROUGH VESTIBULAR AND TRIGEMINAL REFLEXES IN HEALTHY PEOPLE AND IN PATIENTS WITH
MULTIPLE SCLEROSIS / Giaconi, E; Pilurzi, G; Coiana, J; Magnano, I; Cabboi, Mp; Achene, A; Salis, A; Conti, Maurizio; Pes, G; Tolu, E; Deriu, Franca. - In: ACTA PHYSIOLOGICA. - ISSN 1748-1708. - 203:Supplement 688(2011). (Intervento presentato al convegno The 62nd National Congress of the Italian Physiological Society tenutosi a Sorrento, Italy nel 25/09/2011-27/09/2011) [10.13140/2.1.3633.4404].
Abstract:
The acoustic-masseteric reflex (AMR) and the vestibulo-masseteric reflex (VMR) were
recently characterized, but their normal values have not been standardized yet. In
addition, their use to test brainstem (BS) function in neurological diseases has never
been considered before. This study purposed a) to standardize normal values of VMR
and AMR in healthy subjects, in whom vestibulo-collic (VCR) and trigemino-collic (TCR)
reflexes were also recorded; b) to evaluate such brainstem reflexes (BSR) in multiple
sclerosis (MS) patients comparing their data with controls; c) to correlate BSR data to
those obtained from clinical, evoked potential (EP) and neuroimaging (MRI)
assessment.
AMR, VMR, VCR and TCR were investigated in 43 controls and in 39 patients with
relapsing-remitting MS, who underwent additional neurological, EP and MRI
assessment.
The frequency of altered BSR was significantly different (p=0.00001) in controls and in
MS, who showed BSR abnormalities in 92.3% of cases. The True Positive Fraction of
having at least 1, 2, 3 or 4 altered reflexes was 92.3%,74.4%,43.6% and 17.9%
respectively. By comparison, clinical, EP and MRI procedures detected BS involvement
in 46.4%, 76.9% and 74.4% of MS, respectively.
BSR under study test different pathways from the pons to the most caudal part of the
medulla. Data suggest that their combined assessment may provide additional
functional evaluation of BS integrity that may well assist conventional testing.
recently characterized, but their normal values have not been standardized yet. In
addition, their use to test brainstem (BS) function in neurological diseases has never
been considered before. This study purposed a) to standardize normal values of VMR
and AMR in healthy subjects, in whom vestibulo-collic (VCR) and trigemino-collic (TCR)
reflexes were also recorded; b) to evaluate such brainstem reflexes (BSR) in multiple
sclerosis (MS) patients comparing their data with controls; c) to correlate BSR data to
those obtained from clinical, evoked potential (EP) and neuroimaging (MRI)
assessment.
AMR, VMR, VCR and TCR were investigated in 43 controls and in 39 patients with
relapsing-remitting MS, who underwent additional neurological, EP and MRI
assessment.
The frequency of altered BSR was significantly different (p=0.00001) in controls and in
MS, who showed BSR abnormalities in 92.3% of cases. The True Positive Fraction of
having at least 1, 2, 3 or 4 altered reflexes was 92.3%,74.4%,43.6% and 17.9%
respectively. By comparison, clinical, EP and MRI procedures detected BS involvement
in 46.4%, 76.9% and 74.4% of MS, respectively.
BSR under study test different pathways from the pons to the most caudal part of the
medulla. Data suggest that their combined assessment may provide additional
functional evaluation of BS integrity that may well assist conventional testing.
Tipologia CRIS:
4.2 Abstract in Atti di convegno
Elenco autori:
Giaconi, E; Pilurzi, G; Coiana, J; Magnano, I; Cabboi, Mp; Achene, A; Salis, A; Conti, Maurizio; Pes, G; Tolu, E; Deriu, Franca
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