Formation of Mixed‐Valence Cage‐Like Polyoxidovanadates at 37°C Upon Reaction of VIVO(acetylacetonato)2 With Lysozyme

Crystals of the model protein lysozyme were grown and soaked with the potential drug VIVO(acetylacetonato)2 at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.