Data di Pubblicazione:
2005
Citazione:
Modeled microgravity modifies the Na+, K+-ATPase activity in rat heart homogenates / Peana, Alessandra Tiziana; Pippia, P; Paci, S; Tognacini, C; Assaretti, Ar; Meloni, M; Galleri, G; Bennardini, Federico. - In: JOURNAL OF GRAVITATIONAL PHYSIOLOGY. - ISSN 1077-9248. - 12:1(2005), pp. 105-106. (Intervento presentato al convegno 26th Annual GRAVITATIONAL PHYSIOLOGY Meeting tenutosi a Cologne, Germany nel 26-1 July 2005).
Abstract:
This study was aimed at establishing whether modeled
microgravity conditions, created in a three-dimensional
c1inostat (Random Positioning Machine, RPM), influ-
ence the membrane-associated Na+, K+- and Mg2+-
ATPase activities in heart homogenates from rats (ex-
posed to RPM for 48 hours). The experimental data in-
dicate that modeled low g significantly decreased the
total ATPase (p
compared to the respective rat contro I groups (ground).
This Na+, K+- pump inhibition could cause a digital-
like effect in response to several modifications of many
physiological processes even if this inhibition might
also be causally related to the physiological environ-
ment induced by RPM. The exact mechanism by which
total A TPase and Na +, K+ -A TPase activities decrease
in response to RPM conditions remains to be estab-
lished. We cannot mie out that a reduced intracellular
A TP production, previously demonstrated in other cel-
lular systems submitted to modeled microgravity con-
ditions, could be responsible for the effects reported here.
microgravity conditions, created in a three-dimensional
c1inostat (Random Positioning Machine, RPM), influ-
ence the membrane-associated Na+, K+- and Mg2+-
ATPase activities in heart homogenates from rats (ex-
posed to RPM for 48 hours). The experimental data in-
dicate that modeled low g significantly decreased the
total ATPase (p
compared to the respective rat contro I groups (ground).
This Na+, K+- pump inhibition could cause a digital-
like effect in response to several modifications of many
physiological processes even if this inhibition might
also be causally related to the physiological environ-
ment induced by RPM. The exact mechanism by which
total A TPase and Na +, K+ -A TPase activities decrease
in response to RPM conditions remains to be estab-
lished. We cannot mie out that a reduced intracellular
A TP production, previously demonstrated in other cel-
lular systems submitted to modeled microgravity con-
ditions, could be responsible for the effects reported here.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Peana, Alessandra Tiziana; Pippia, P; Paci, S; Tognacini, C; Assaretti, Ar; Meloni, M; Galleri, G; Bennardini, Federico
Link alla scheda completa:
Titolo del libro:
JOURNAL OF GRAVITATIONAL PHYSIOLOGY
Pubblicato in: