Multi-Residue Analysis of eight Thioamphetamine Designer Drugs in Human Urine by Liquid Chromatography/Tandem Mass Spectrometry
Articolo
Data di Pubblicazione:
2009
Citazione:
Multi-Residue Analysis of eight Thioamphetamine Designer Drugs in Human Urine by Liquid Chromatography/Tandem Mass Spectrometry / M., N., Boatto, G., Pirisi, M.A., E., B.. - In: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. - ISSN 0951-4198. - 23:19(2009), pp. 3051-3056. [10.1002/rcm.4219]
Abstract:
An analytical procedure for the simultaneous determination in human urine of several thioamphetamine
designer drugs (2C-T and ALEPH series) is reported. The quantitative analysis was performed
by liquid chromatography/tandem mass spectrometry and has been fully validated. The mass
spectrometer was operated in positive-ion, selected reaction monitoring (SRM) mode. In order to
minimize interferences with matrix components and to preconcentrate target analytes, solid-phase
extraction was introduced in the method as a clean-up step. The entire method was validated for
selectivity, linearity, precision and accuracy. The method turned out to be specific, sensitive, and
reliable for the analysis of amphetamine derivatives in urine samples. The calibration curves were
linear over the concentration range of 1 to 100 ngmL1 for all drugs with correlation coefficients that
exceeded 0.996. The lower limits of detection (LODs) and quantification (LOQs) ranged from 1.2 to
4.9 ngmL1 and from 3.2 to 9.6 ngmL1, respectively.
designer drugs (2C-T and ALEPH series) is reported. The quantitative analysis was performed
by liquid chromatography/tandem mass spectrometry and has been fully validated. The mass
spectrometer was operated in positive-ion, selected reaction monitoring (SRM) mode. In order to
minimize interferences with matrix components and to preconcentrate target analytes, solid-phase
extraction was introduced in the method as a clean-up step. The entire method was validated for
selectivity, linearity, precision and accuracy. The method turned out to be specific, sensitive, and
reliable for the analysis of amphetamine derivatives in urine samples. The calibration curves were
linear over the concentration range of 1 to 100 ngmL1 for all drugs with correlation coefficients that
exceeded 0.996. The lower limits of detection (LODs) and quantification (LOQs) ranged from 1.2 to
4.9 ngmL1 and from 3.2 to 9.6 ngmL1, respectively.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
M., Nieddu; Boatto, Gianpiero; Pirisi, Maria Antonietta; E., Baralla
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