Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors
Articolo
Data di Pubblicazione:
2008
Citazione:
Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors / Sechi, Mario; Azzena, Ugo Gavino; MARIA PAOLA, Delussu; Roberto, Dallocchio; Alessandro, Dessì; Alessia, Cosseddu; Nicolino, Pala; Nouri, Neamati. - In: MOLECULES. - ISSN 1420-3049. - 13:(2008), pp. 2442-2461. [10.3390/molecules13102442]
Abstract:
HIV-1 integrase (IN) is an attractive and validated target for the development of
novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and
synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid.
We performed a docking study to investigate the potential interactions of the title
compounds with essential amino acids on the IN active site.
novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and
synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid.
We performed a docking study to investigate the potential interactions of the title
compounds with essential amino acids on the IN active site.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Bis-amides; HIV-1; HIV-1 integrase
Elenco autori:
Sechi, Mario; Azzena, Ugo Gavino; MARIA PAOLA, Delussu; Roberto, Dallocchio; Alessandro, Dessì; Alessia, Cosseddu; Nicolino, Pala; Nouri, Neamati
Link alla scheda completa:
Pubblicato in: