Synthesis and antiproliferative activity of 3-aryl-2-[1H(2H)-benzotriazol-1(2)-yl]acrylonitriles variously substituted: Part 4
Articolo
Data di Pubblicazione:
2004
Citazione:
Synthesis and antiproliferative activity of 3-aryl-2-[1H(2H)-benzotriazol-1(2)-yl]acrylonitriles variously substituted: Part 4 / Carta, Antonio; Palomba, Michele Francesco Luigi; Boatto, Gianpiero; B., Busonera; M., Murreddu; R., Loddo. - In: IL FARMACO. - ISSN 0014-827X. - 59:8(2004), pp. 637-644. [10.1016/j.farmac.2004.03.004]
Abstract:
A new series of variously substituted 3-aryl-2-[1H(2H)-benzotriazol-1(2)yl]acrylonitriles was synthesized and tested for antiproliferative and antitubercular activity as part of our continuing research program in the antimicrobial and antitumor fields. The most cytotoxic derivatives(5a,g,i,j,l and 7b) (CC50 <3.0 µM against MT-4cells) were evaluated against a panel of human cell lines derived from hematological ands olid
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Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
3-Aryl-2-(1H(2H)-benzotriazol-1(2)-yl)acrylonitriles ; Antiproliferative activity ; Antitubercular screening
Elenco autori:
Carta, Antonio; Palomba, Michele Francesco Luigi; Boatto, Gianpiero; B., Busonera; M., Murreddu; R., Loddo
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