The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
Articolo
Data di Pubblicazione:
2022
Citazione:
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease / Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022), p. 192. [10.1186/s13046-022-02394-2]
Abstract:
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
AKT; Hippo pathway; Intrahepatic cholangiocarcinoma; Notch; TAZ; TEAD transcription factors; Adaptor Proteins, Signal Transducing; Animals; Bile Ducts, Intrahepatic; Hippo Signaling Pathway; Humans; Mice; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; YAP-Signaling Proteins; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma
Elenco autori:
Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja
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