Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance.
Articolo
Data di Pubblicazione:
1997
Citazione:
Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance / Versalovic, J; Osato, Ms; Spakovsky, K; Dore, Maria Pina; Reddy, R; Stone, Gg; Shortridge, D; Flamm, Rk; Tanaka, Sk; Graham, D. Y.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 40:2(1997), pp. 283-286. [10.1093/jac/40.2.283]
Abstract:
Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different
patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G)
mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely
to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation;
P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs
exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients
infected with H. pylori strains containing either the A2143G or the A2144G mutation.
patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G)
mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely
to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation;
P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs
exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients
infected with H. pylori strains containing either the A2143G or the A2144G mutation.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Versalovic, J; Osato, Ms; Spakovsky, K; Dore, Maria Pina; Reddy, R; Stone, Gg; Shortridge, D; Flamm, Rk; Tanaka, Sk; Graham, D. Y.
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