Immunohistochemistry and biomolecular investigation for the evidence of JSRV-like retrovirus in human bronchiolo-alveolar carcinomas
Abstract
Data di Pubblicazione:
2005
Citazione:
Immunohistochemistry and biomolecular investigation for the evidence of JSRV-like retrovirus in human bronchiolo-alveolar carcinomas / Rocca, Stefano; Pirino, Salvatore; Farigu, Serafina; Cossu, Antonio; Lissia, Amelia; Leoni, Antonio; Sanna, Maria Paola; Palmieri, Giuseppe. - In: ATTI ... CONVEGNO NAZIONALE AIPVET. - ISSN 1825-2265. - (2005), pp. 27-30. (Intervento presentato al convegno 2. Congresso nazionale A.I.P.Vet.: atti).
Abstract:
The bronchioloalveolar adenocarcinoma was described in several species (human, bovine, ovine and domestic
carnivores). Ovine pulmonary adenocarcinoma (OPA) or pulmonary adenomatosis is a contagious carcinoma of sheep
caused by an exogenous type D retrovirus denominated also jaagsiekte sheep retrovirus (JSRV). JSRV is responsible of
the neoplastic transformation of type II pneumocytes and Clara cells. The human bronchioloalveolar adenocarcinoma
(BAC) have histo-morphological features much similar to OPA. We report the study about ten BAC cases and one
negative human control (lung). DNA extraction, PCR, sequencing of amplified product, immunohistochemistry and insitu
hybridization were performed on all paraffin-embedded samples. Our results demonstrated the presence of JSRVlike
sequences in all cases of human bronchiolo-alveolar carcinoma.
carnivores). Ovine pulmonary adenocarcinoma (OPA) or pulmonary adenomatosis is a contagious carcinoma of sheep
caused by an exogenous type D retrovirus denominated also jaagsiekte sheep retrovirus (JSRV). JSRV is responsible of
the neoplastic transformation of type II pneumocytes and Clara cells. The human bronchioloalveolar adenocarcinoma
(BAC) have histo-morphological features much similar to OPA. We report the study about ten BAC cases and one
negative human control (lung). DNA extraction, PCR, sequencing of amplified product, immunohistochemistry and insitu
hybridization were performed on all paraffin-embedded samples. Our results demonstrated the presence of JSRVlike
sequences in all cases of human bronchiolo-alveolar carcinoma.
Tipologia CRIS:
4.2 Abstract in Atti di convegno
Keywords:
Bronchioloalveolar adenocarcinoma; sheep pulmonary adenomatosis; in-situ hybridization;
immunohistochemistry
Elenco autori:
Rocca, Stefano; Pirino, Salvatore; Farigu, Serafina; Cossu, Antonio; Lissia, Amelia; Leoni, Antonio; Sanna, Maria Paola; Palmieri, Giuseppe
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