Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications
Articolo
Data di Pubblicazione:
2012
Citazione:
Medicinal gold compounds form tight adducts with the copper chaperone
Atox-1: biological and pharmacological implications / Gabbiani, C; Scaletti, F; Massai, L; Michelucci, E; Cinellu, Maria Agostina; Messori, L.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:(2012), pp. 11623-11625. [10.1039/c2cc36610j]
Abstract:
Based on ESI-MS measurements, we show here that some representative
cytotoxic gold(III) compounds produce stable adducts
upon reaction with the copper chaperone Atox-1; notably, such
adducts contain gold in the oxidation state +1. These findings are
of interest to understand the intracellular metabolism of medicinal
gold species and to develop new potent inhibitors of the copper
trafficking system.
cytotoxic gold(III) compounds produce stable adducts
upon reaction with the copper chaperone Atox-1; notably, such
adducts contain gold in the oxidation state +1. These findings are
of interest to understand the intracellular metabolism of medicinal
gold species and to develop new potent inhibitors of the copper
trafficking system.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
gold drugs; Atox-1; ESI-MS
Elenco autori:
Gabbiani, C; Scaletti, F; Massai, L; Michelucci, E; Cinellu, Maria Agostina; Messori, L.
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