Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro
Academic Article
Publication Date:
2014
Short description:
Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro / Serratice, M., Bertrand, B., Janssen, E., Hemelt, E., Zucca, A., Cocco, F., Cinellu, M.A., Casini, A.. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 5:(2014), pp. 1418-1422. [10.1039/c4md00241e]
abstract:
A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced
precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have
been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic
cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated
mechanism.
precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have
been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic
cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated
mechanism.
Iris type:
1.1 Articolo in rivista
Keywords:
gold-based drugs; proton pump; antitumor activity
List of contributors:
Serratice, M; Bertrand, B; Janssen, Efj; Hemelt, E; Zucca, Antonio; Cocco, Fabio; Cinellu, Maria Agostina; Casini, A.
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