Data di Pubblicazione:
2004
Citazione:
Solution chemistry and cytotoxic properties of novel organogold(III) compounds / Messori, L.; Marcon, G.; Cinellu, Maria Agostina; Coronnello, M.; Mini, E; Gabbiani, C.; Orioli, P.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 12:(2004), pp. 6039-6043.
Abstract:
The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties
evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following
compounds were considered: [Au(bipydmb-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipydmb-H)(p-toluidine-H)][PF6] (AuTol)
(in which bipydmb = 6-(1,1-dimethylbenzyl)-2,20-bipyridine), [Au(pydmb-H)(AcO)2] (AuPyAcO) (in which pydmb = 2-(1,1-dimethylbenzyl)-
pyridine) and [Au(pzPh-H)Cl3]K (AuPzCl) (in which pzPh = 1-phenylpyrazole). The solution chemistry of these
compounds, under physiological-like conditions, was investigated through UV–vis absorption and 1H NMR spectroscopies. Significant
cytotoxic effects in vitro were observed in selected cases.
evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following
compounds were considered: [Au(bipydmb-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipydmb-H)(p-toluidine-H)][PF6] (AuTol)
(in which bipydmb = 6-(1,1-dimethylbenzyl)-2,20-bipyridine), [Au(pydmb-H)(AcO)2] (AuPyAcO) (in which pydmb = 2-(1,1-dimethylbenzyl)-
pyridine) and [Au(pzPh-H)Cl3]K (AuPzCl) (in which pzPh = 1-phenylpyrazole). The solution chemistry of these
compounds, under physiological-like conditions, was investigated through UV–vis absorption and 1H NMR spectroscopies. Significant
cytotoxic effects in vitro were observed in selected cases.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
organogold; gold drugs; antitumor activity
Elenco autori:
Messori, L.; Marcon, G.; Cinellu, Maria Agostina; Coronnello, M.; Mini, E; Gabbiani, C.; Orioli, P.
Link alla scheda completa:
Pubblicato in: