Metal complexes of 2,4-diamino-5-(3′,4′,5′-trimethoxybenzyl)pyrimidine (trimethoprim) Part IV. Synthesis and X-ray structure of [CuCl(μ-OCH3)(trimethoprim)]2

The reaction of CuCl2·2H2O with trimethoprim in a methanolic solution affords the [CUCl(μ-OCH3)(trimethoprim)]2 dimeric complex (1) which has been characterized by single crystal X-ray diffraction. Compound 1 is monoclinic, space group P21/n with a=12.091(2), b=7.647(3), c=19.815(5) Å, β=96.63(2)°, Z=2, R=0.044, Rw=0.047 for 1562 observed reflections with I>2σ(I). The two copper atoms are held together by methoxo bridges and coordinate one terminal chlorine atom and one trimethoprim ligand each, the latter behaving as a monodentate ligand through a pyrimidinic nitrogen atom. © 1990.