The association of adult height with the risk of cardiovascular disease and cancer in the population of Sardinia
Articolo
Data di Pubblicazione:
2018
Citazione:
The association of adult height with the risk of cardiovascular disease and cancer in the population of Sardinia / Pes, Giovanni Mario; Ganau, Antonello; Tognotti, Eugenia; Errigo, Alessandra; Rocchi, Chiara; Dore, Maria Pina. - In: PLOS ONE. - ISSN 1932-6203. - 13:4(2018). [10.1371/journal.pone.0190888]
Abstract:
Background: The relationship between body height and the risk of non‒communicable
diseases such as cardiovascular disease and cancer has been the subject of much
debate in the epidemiological literature. Concerns have recently arisen over spurious
associations due to confounding factors like birth cohort, especially in the context of
epidemiological transition. The population of Sardinia represents an interesting case
study, as the average physical stature of inhabitants was the lowest recorded in
Europe until a few decades ago. In this population we tested whether height is an
independent risk factor for cardiovascular disease and cancer.
Methods: We analysed the stature of 10,427 patients undergoing endoscopy for any
reason, for whom a detailed clinical history of cardiovascular disease and/or
malignancies had been documented. Poisson regression modelling was used to test
the association between stature and disease risk.
Results: When patients were subdivided according to sex and height tertiles, the risk of
cardiovascular disease proved significantly greater for subjects in the lowest tertile
irrespective of sex (men: 1.87; 95%CI 1.41‒2.47; women: 1.23; 95%CI 0.92‒1.66) and
smaller for those in the highest tertile (men: 0.51; 95%CI 0.35‒0.75; women: 0.41;
95%CI 0.27‒0.61). However, after adjusting the risk for birth cohort and established
risk factors, it mostly resulted in non-significant values, although the overall trend
persisted. Similar results were obtained for all-cancer risk (relative risk for men and
women in the lowest tertile: 1.44; 95%CI 1.09-1.90 and 1.17; 95%CI 0.93-1.48, in the
highest tertile: 0.51; 95%CI 0.36-0.72 and 0.62; 95%CI 0.47-0.81, respectively) as well
as for some of the most common types of cancer.
Conclusion: The risk of occurrence of cardiovascular disease and malignancies does
not vary significantly with stature in the Sardinian population, after adjusting for birth
cohort and more obvious risk factors.
diseases such as cardiovascular disease and cancer has been the subject of much
debate in the epidemiological literature. Concerns have recently arisen over spurious
associations due to confounding factors like birth cohort, especially in the context of
epidemiological transition. The population of Sardinia represents an interesting case
study, as the average physical stature of inhabitants was the lowest recorded in
Europe until a few decades ago. In this population we tested whether height is an
independent risk factor for cardiovascular disease and cancer.
Methods: We analysed the stature of 10,427 patients undergoing endoscopy for any
reason, for whom a detailed clinical history of cardiovascular disease and/or
malignancies had been documented. Poisson regression modelling was used to test
the association between stature and disease risk.
Results: When patients were subdivided according to sex and height tertiles, the risk of
cardiovascular disease proved significantly greater for subjects in the lowest tertile
irrespective of sex (men: 1.87; 95%CI 1.41‒2.47; women: 1.23; 95%CI 0.92‒1.66) and
smaller for those in the highest tertile (men: 0.51; 95%CI 0.35‒0.75; women: 0.41;
95%CI 0.27‒0.61). However, after adjusting the risk for birth cohort and established
risk factors, it mostly resulted in non-significant values, although the overall trend
persisted. Similar results were obtained for all-cancer risk (relative risk for men and
women in the lowest tertile: 1.44; 95%CI 1.09-1.90 and 1.17; 95%CI 0.93-1.48, in the
highest tertile: 0.51; 95%CI 0.36-0.72 and 0.62; 95%CI 0.47-0.81, respectively) as well
as for some of the most common types of cancer.
Conclusion: The risk of occurrence of cardiovascular disease and malignancies does
not vary significantly with stature in the Sardinian population, after adjusting for birth
cohort and more obvious risk factors.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
body height
Elenco autori:
Pes, Giovanni Mario; Ganau, Antonello; Tognotti, Eugenia; Errigo, Alessandra; Rocchi, Chiara; Dore, Maria Pina
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